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Article

HLA-DPB1 E69 genotype and exposure in beryllium sensitisation and disease.

Occupational and environmental medicine - 1 Feb 2022

Crooks James, Mroz Margaret M, VanDyke Michael, McGrath Alison, Schuler Christine, McCanlies Erin C, Virji M Abbas, Rosenman Kenneth D, Rossman Milton, Rice Carol, Monos Dimitri, Fingerlin Tasha E, Maier Lisa A

Abstract excerpt

OBJECTIVES: Human leukocyte antigen-DP beta 1 (HLA-DPB1) with a glutamic acid at the 69th position of the ß chain (E69) genotype and inhalational beryllium exposure individually contribute to risk of chronic beryllium disease (CBD) and beryllium sensitisation (BeS) in exposed individuals. This retrospective nested case-control study assessed the contribution of genetics and exposure in the development of BeS and...

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Identifiers

PMID: 34535537
DOI: 10.1136/oemed-2021-107736
PMCID: PMC8760148

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