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Article

Differential susceptibilities to chronic beryllium disease contributed by different Glu69 HLA-DPB1 and -DPA1 alleles.

Journal of immunology (Baltimore, Md. : 1950) - 1 Aug 1999

Wang Z, White P S, Petrovic M, Tatum O L, Newman L S, Maier L A, Marrone B L

Abstract excerpt

Chronic beryllium disease (CBD) is associated with the allelic substitution of a Glu69 in the HLA-DPB1 gene. Although up to 97% of CBD patients may have the Glu69 marker, about 30-45% of beryllium-exposed, unaffected individuals carry the same marker. Because CBD occurs in only 1-6% of exposed workers, the presence of Glu69 does not appear to be the sole genetic factor underlying the disease development. Using...

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PMID: 10415070

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