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Article

Linking genetic susceptibility and T cell activation in beryllium-induced disease.

Proceedings of the American Thoracic Society - 1 May 2010

Falta Michael T, Bowerman Natalie A, Dai Shaodong, Kappler John W, Fontenot Andrew P

Abstract excerpt

Chronic beryllium disease (CBD) is a granulomatous lung disorder caused by beryllium (Be) exposure in the workplace. It is characterized by the accumulation of Be-specific CD4(+) T cells in the lung as well as persistent lung inflammation, culminating in the development of lung fibrosis. CBD occurs in 2 to 16% of Be-exposed workers depending on the individuals' genetic susceptibility and the characteristics of...

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Share to CD4-Positive T-Lymphocytes
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Identifiers

PMID: 20427584
DOI: 10.1513/pats.201002-022RM
PMCID: PMC3266018

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Source receipt: pubmed, retrieved 7 Sept 2026.

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