Article
Risk of chronic beryllium disease by HLA-DPB1 E69 genotype and beryllium exposure in nuclear workers.
American journal of respiratory and critical care medicine - 15 Jun 2011
Van Dyke Mike V, Martyny John W, Mroz Margaret M, Silveira Lori J, Strand Matt, Fingerlin Tasha E, Sato Hiroe, Newman Lee S, Maier Lisa A
Abstract excerpt
RATIONALE: Beryllium sensitization (BeS) and chronic beryllium disease (CBD) are determined by at least one genetic factor, a glutamic acid at position 69 (E69) of the HLA-DPB1 gene, and by exposure to beryllium. The relationship between exposure and the E69 genotype has not been well characterized. OBJECTIVES: The study goal was to define the relationship between beryllium exposure and E69 for CBD and BeS....
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