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Article

HLA class II DPB1 and DRB1 polymorphisms associated with genetic susceptibility to beryllium toxicity.

Occupational and environmental medicine - 1 Jul 2011

Rosenman K D, Rossman M, Hertzberg V, Reilly M J, Rice C, Kanterakis E, Monos D

Abstract excerpt

OBJECTIVES: Chronic beryllium disease (CBD) is a hypersensitivity granulomatous pulmonary disease caused by exposure to the metal beryllium (Be²⁺). Our objective was to extend current knowledge of the genetics of beryllium disease by examining all HLA-DPB1 and HLA-DPR1 gene polymorphisms and the interactions between them. METHODS: DNA-based typing of HLA-DPB1 and HLA-DRB1 loci at the allele level was performed on...

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Identifiers

PMID: 21186201
DOI: 10.1136/oem.2010.055046

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