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Article

UPF1 shuttles between nucleus and cytoplasm independently of its RNA-binding and ATPase activities.

RNA (New York, N.Y.) - 17 Nov 2025

Nasif Sofia, Eberle Andrea Brigitte, Schranz Karin, Hadorn Remo, Chakrabarti Sutapa, Mühlemann Oliver

Abstract excerpt

The ATP-dependent RNA helicase Up-frameshift 1 (UPF1) is an essential protein in mammalian cells and a key factor in nonsense-mediated mRNA decay (NMD), a translation-dependent mRNA surveillance process. UPF1 is mainly cytoplasmic at steady state but accumulates in the nucleus after inhibiting CRM1-mediated nuclear export by leptomycin B (LMB), indicating that UPF1 shuttles between the nucleus and the cytoplasm....

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Topics

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41057268
DOI: 10.1261/rna.080476.125
PMCID: PMC12621600

Genes

UPF1
SMG6
UPF2
UPF3B

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

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UPF1 shuttles between nucleus and cytoplasm independently of its RNA-binding and ATPase activities.PMID 41057268Read ↗

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