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Article

ATP is a cofactor of the Upf1 protein that modulates its translation termination and RNA binding activities.

RNA (New York, N.Y.) - 1 Feb 1998

Weng Y, Czaplinski K, Peltz S W

Abstract excerpt

The nonsense-mediated mRNA decay pathway decreases the abundance of mRNAs that contain premature termination codons and prevents suppression of nonsense alleles. The UPF1 gene in the yeast Saccharomyces cerevisiae was shown to be a trans-acting factor in this decay pathway. The Upf1p demonstrates RNA-dependent ATPase, RNA helicase, and RNA binding activities. The results presented here investigate the binding...

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Identifiers

PMID: 9570320
PMCID: PMC1369609

Genes

UPF1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Click a neighbor to travelStep 1 · 12 closest

ATP is a cofactor of the Upf1 protein that modulates its translation termination and RNA binding activities.PMID 9570320Read ↗

ATP hydrolysis by UPF1 is required for efficient translation termination at premature stop codons.Semantic proximity Read ↗

Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.Semantic proximity Read ↗

Target Discrimination in Nonsense-Mediated mRNA Decay Requires Upf1 ATPase Activity.Semantic proximity Read ↗

UPF1 shuttles between nucleus and cytoplasm independently of its RNA-binding and ATPase activities.Semantic proximity Read ↗

UPF1 ATPase autoinhibition and activation modulate RNA binding kinetics and NMD efficiency.Semantic proximity Read ↗

The Double Life of UPF1 in RNA and DNA Stability PathwaysSemantic proximity Read ↗

An alternative UPF1 isoform drives conditional remodeling of nonsense-mediated mRNA decaySemantic proximity Read ↗

Identification of an evolutionary conserved binding motif responsible for the recruitment of NMD factors to the UPF1 helicaseSemantic proximity Read ↗

The product of the yeast UPF1 gene is required for rapid turnover of mRNAs containing a premature translational termination codon.Semantic proximity Read ↗

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Semantic proximity Read ↗

Overexpression of Upf1p compensates for mitochondrial splicing deficiency independently of its role in mRNA surveillance.Semantic proximity Read ↗

A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells.Semantic proximity Read ↗

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