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Article

HTLV-1 Tax plugs and freezes UPF1 helicase leading to nonsense-mediated mRNA decay inhibition.

Nature communications - 30 Jan 2018

Fiorini Francesca, Robin Jean-Philippe, Kanaan Joanne, Borowiak Malgorzata, Croquette Vincent, Le Hir Hervé, Jalinot Pierre, Mocquet Vincent

Abstract excerpt

Up-Frameshift Suppressor 1 Homolog (UPF1) is a key factor for nonsense-mediated mRNA decay (NMD), a cellular process that can actively degrade mRNAs. Here, we study NMD inhibition during infection by human T-cell lymphotropic virus type I (HTLV-1) and characterise the influence of the retroviral Tax factor on UPF1 activity. Tax interacts with the central helicase core domain of UPF1 and might plug the RNA channel...

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Identifiers

PMID: 29382845
DOI: 10.1038/s41467-017-02793-6
PMCID: PMC5789848

Genes

UPF1

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