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Article

Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.

RNA (New York, N.Y.) - 1 Sept 2000

Bhattacharya A, Czaplinski K, Trifillis P, He F, Jacobson A, Peltz S W

Abstract excerpt

The Upf1 protein in yeast has been implicated in the modulation of efficient translation termination as well as in the accelerated turnover of mRNAs containing premature stop codons, a phenomenon called nonsense-mediated mRNA decay (NMD). A human homolog of the yeast UPF1, termed HUpf1/RENT1, has also been identified. The HUpf1 has also been shown to play a role in NMD in mammalian cells. Comparison of the yeast...

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Identifiers

PMID: 10999600
DOI: 10.1017/s1355838200000546
PMCID: PMC1369996

Genes

UPF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of the biochemical properties of the human Upf1 gene product that is involved in nonsense-mediated mRNA decay.PMID 10999600Read ↗

Cloning and characterization of HUPF1, a human homolog of the Saccharomyces cerevisiae nonsense mRNA-reducing UPF1 proteinSemantic proximity Read ↗

A mutated human homologue to yeast Upf1 protein has a dominant-negative effect on the decay of nonsense-containing mRNAs in mammalian cells.Semantic proximity Read ↗

UPF1-From mRNA Degradation to Human Disorders.Semantic proximity Read ↗

The Double Life of UPF1 in RNA and DNA Stability PathwaysSemantic proximity Read ↗

Identification and characterization of human orthologues to Saccharomyces cerevisiae Upf2 protein and Upf3 protein (Caenorhabditis elegans SMG-4).Semantic proximity Read ↗

ATP is a cofactor of the Upf1 protein that modulates its translation termination and RNA binding activities.Semantic proximity Read ↗

Identification of an evolutionary conserved binding motif responsible for the recruitment of NMD factors to the UPF1 helicaseSemantic proximity Read ↗

An alternative UPF1 isoform drives conditional remodeling of nonsense-mediated mRNA decaySemantic proximity Read ↗

A highly conserved region essential for NMD in the Upf2 N-terminal domain.Semantic proximity Read ↗

Overexpression of Upf1p compensates for mitochondrial splicing deficiency independently of its role in mRNA surveillance.Semantic proximity Read ↗

Upf1/Upf2 regulation of 3' untranslated region splice variants of AUF1 links nonsense-mediated and A+U-rich element-mediated mRNA decay.Semantic proximity Read ↗

Upf proteins: highly conserved factors involved in nonsense mRNA mediated decay.Semantic proximity Read ↗

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