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Article

Processing bodies are not required for mammalian nonsense-mediated mRNA decay.

RNA (New York, N.Y.) - 1 Jul 2009

Stalder Lukas, Mühlemann Oliver

Abstract excerpt

Nonsense-mediated mRNA decay (NMD) is a eukaryotic quality-control mechanism that recognizes and degrades mRNAs with premature termination codons (PTCs). In yeast, PTC-containing mRNAs are targeted to processing bodies (P-bodies), and yeast strains expressing an ATPase defective Upf1p mutant accumulate P-bodies. Here we show that in human cells, an ATPase-deficient UPF1 mutant and a fraction of UPF2 and UPF3b...

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Source

Open in PubMed Open full text

Identifiers

PMID: 19474145
DOI: 10.1261/rna.1672509
PMCID: PMC2704072

Genes

UPF1
UPF2
SMG1
SMG6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Processing bodies are not required for mammalian nonsense-mediated mRNA decay.PMID 19474145Read ↗

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