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Article

Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development in mice.

The Journal of clinical investigation - 1 Dec 2025

Yan Bowen, Yuan Qingchen, Buttigieg Marco M, Kaur Prabhjot, McKee Annalisse R, Shabashvili Daniil E, Vlasschaert Caitlyn, Bick Alexander G, Rauh Michael J, Guryanova Olga A

Abstract excerpt

#ClonalHematopoiesis, an #aging related condition caused by mutations in the #blood system, promotes #obesity, and with high-fat #diet drives the risk of #diabetes and #MASLD.

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Source

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Identifiers

PMID: 41027007
DOI: 10.1172/JCI197100
PMCID: PMC12646656

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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