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Article

Clonal hematopoiesis of indeterminate potential: a unifying mechanism linking metainflammation and cardiometabolic diseases.

American journal of physiology. Heart and circulatory physiology - 1 Dec 2025

Wimalarathne Nethma Savindi, Lan Nick S R, George Jacob, Sharma Ankur, Adams Leon A, Dwivedi Girish

Abstract excerpt

Clonal hematopoiesis of indeterminate potential (CHIP) refers to the age-related expansion of hematopoietic stem cells bearing somatic mutations in the absence of overt hematological malignancy. Emerging evidence suggests that CHIP is not merely a marker of aging, but an active driver of metainflammation, a chronic systemic inflammatory state arising from metabolic dysregulation. Indeed, several studies have...

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PMID: 41101780
DOI: 10.1152/ajpheart.00577.2025

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