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Hematologic DNMT3A reduction and high-fat diet synergize to promote weight gain and tissue inflammation

5 Feb 2024

Abstract excerpt

During aging, blood cell production becomes dominated by a limited number of variant hematopoietic stem cell (HSC) clones. Differentiated progeny of variant HSCs are thought to mediate the detrimental effects of such clonal hematopoiesis on organismal health, but the mechanisms are poorly understood. While somatic mutations in DNA methyltransferase 3A (DNMT3A) frequently drive clonal dominance, the aging milieu...

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PMID: 38414863
DOI: 10.1016/j.isci.2024.109122

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