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Article

Age-related micro-environmental changes as drivers of clonal hematopoiesis.

Current opinion in hematology - 1 Mar 2024

Bacharach Tal, Kaushansky Nathali, Shlush Liran I

Abstract excerpt

PURPOSE OF REVIEW: Both aging and reduced diversity at the hematopoietic stem cells (HSCs) level are ubiquitous. What remains unclear is why some individuals develop clonal hematopoiesis (CH), and why does CH due to specific mutations occur in specific individuals. Much like aging, reduced diversity of HSCs is a complex phenotype shaped by numerous factors (germline & environment). The purpose of the current...

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PMID: 38133628
DOI: 10.1097/MOH.0000000000000798

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