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Article

Clonal hematopoiesis and autoimmunity.

Seminars in hematology - 1 Feb 2024

Kishtagari Ashwin, Corty Robert W, Visconte Valeria

Abstract excerpt

Clonal hematopoiesis (CH) has been associated with aging, occurring in about 10% of individuals aged >70 years, and immune dysfunction. Aged hematopoietic stem and progenitor cells exhibit pathological changes in immune function and activation of inflammatory pathways. CH clones commonly harbor a loss of function mutation in DNMT3A or TET2, which causes increased expression of inflammatory signaling genes, a...

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Identifiers

PMID: 38423847
DOI: 10.1053/j.seminhematol.2024.01.012

Genes

DNMT3A
TET2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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