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Inflammatory signals from fatty bone marrow support DNMT3A driven clonal hematopoiesis

12 Apr 2023

Abstract excerpt

Abstract Both fatty bone marrow (FBM) and somatic mutations in hematopoietic stem cells (HSCs), also termed clonal hematopoiesis (CH) accumulate with human aging. However it remains unclear whether FBM can modify the evolution of CH. To address this question, we herein present the interaction between CH and FBM in two preclinical male mouse models: after sub-lethal irradiation or after castration. An adipogenesis...

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PMID: 37045808
DOI: 10.1038/s41467-023-36906-1

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