Article

Inflammatory signals from fatty bone marrow supports the early stages of <i>DNMT3a</i> driven clonal hematopoiesis

2022-01-14

Abstract excerpt

Age related cancer is not only due to the random accumulation of mutations, but also how phenotypes are selected by the aging environment. While fatty bone marrow (FBM), is one of the hallmarks of bone marrow ageing, it is unknown whether FBM can modify the evolution of the early stages of leukemia and clonal hematopoiesis (CH). To address this question, we established FBM mice models and transplanted both human a...

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Literature Corpus work: 3041322a-2b42-5ec3-ad82-a399276b91d9
DOI: 10.1101/2022.01.13.476218

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