Novel and emerging therapeutic strategies for clonal hematopoiesis.

Abstract excerpt

Clonal hematopoiesis (CH) arises when hematopoietic stem cells (HSC) acquire mutations that confer a competitive advantage over wild-type HSC, leading to their expansion in the bone marrow with clonal progeny that circulate in the blood and are most readily detected through peripheral blood sequencing. The prevalence of CH increases with age and is linked to a higher risk of hematologic malignancies and various...

Topics

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• Clonal Hematopoiesis
• Epigenesis, Genetic
• Hematologic Neoplasms
• Hematopoietic Stem Cells
• Molecular Targeted Therapy