Article
Obesity-induced inflammation exacerbates clonal hematopoiesis.
The Journal of clinical investigation - 1 Jun 2023
Pasupuleti Santhosh Kumar, Ramdas Baskar, Burns Sarah S, Palam Lakshmi Reddy, Kanumuri Rahul, Kumar Ramesh, Pandhiri Taruni Reddy, Dave Utpal P, Yellapu Nanda Kumar, Zhou Xinyu, Zhang Chi, Sandusky George E, Yu Zhi, Honigberg Michael C, Bick Alexander G, Griffin Gabriel K, Niroula Abhishek, Ebert Benjamin L, Paczesny Sophie, Natarajan Pradeep, Kapur Reuben
Abstract excerpt
Characterized by the accumulation of somatic mutations in blood cell lineages, clonal hematopoiesis of indeterminate potential (CHIP) is frequent in aging and involves the expansion of mutated hematopoietic stem and progenitor cells (HSC/Ps) that leads to an increased risk of hematologic malignancy. However, the risk factors that contribute to CHIP-associated clonal hematopoiesis (CH) are poorly understood....
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.