Article

Clonal hematopoiesis driven by Dnmt3a mutations promotes metabolic disease development

2025-05-08

Abstract excerpt

Clonal hematopoiesis (CH) is associated with an increased risk of non-hematologic chronic diseases including metabolic disorders, yet the causality remains poorly defined. DNMT3A is the most frequently altered gene in CH, commonly through monoallelic loss-of-function (LOF) and Arg882His (RH) hotspot mutations. Here we demonstrate in a mouse model that CH driven by Dnmt3a RH and especially LOF promotes obesity, dia...

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Literature Corpus work: bb14ac6f-81f4-5987-b97a-6a1e62bbbe55
DOI: 10.1101/2025.05.02.651715

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