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Article

Sex- and APOE Genotype-Dependent Pain Susceptibility and Alzheimer's Risk Mediated by the Lipid Metabolism Enzyme LPCAT2.

Aging cell - 1 Nov 2025

Lai Rai-Hua, Chung Ren-Hua, Pai Wan-Yu, Chen Yi-Chung, Lam Ka-Hei, Lai Cheng-Nong, Juang Jyh-Lyh

Abstract excerpt

Neuropathological changes that precede or accompany early cognitive decline in Alzheimer's disease (AD) may also impact pain processing; however, the molecular connection between these domains remains unclear. In this study, we investigated whether a shared causal factor underlies both increased pain susceptibility and AD progression. Analysis of two ethnically distinct cohorts revealed a significant association...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40959955
DOI: 10.1111/acel.70234
PMCID: PMC12611278

Genes

LPCAT2
APOE

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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