Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes.

PloS one - 1 Jan 2012

Jun Gyungah, Moncaster Juliet A, Koutras Carolina, Seshadri Sudha, Buros Jacqueline, McKee Ann C, Levesque Georges, Wolf Philip A, St George-Hyslop Peter, Goldstein Lee E, Farrer Lindsay A

Abstract excerpt

Multiple lines of evidence suggest that specific subtypes of age-related cataract (ARC) and Alzheimer disease (AD) are related etiologically. To identify shared genetic factors for ARC and AD, we estimated co-heritability of quantitative measures of cataract subtypes with AD-related brain MRI tra...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amyloid beta-Peptides
Share to Base Pairing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cataract

Share to Catenins

Share to Delta Catenin

Share to Lateral Ventricles

Share to Lens, Crystalline

Share to Organ Size

Source

Open in PubMed Open full text

Identifiers

PMID: 22984439
DOI: 10.1371/journal.pone.0043728
PMCID: PMC3439481

Genes

ARC
CTNND2
APP

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22984439-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

δ-Catenin is genetically and biologically associated with cortical cataract and future Alzheimer-related structural and functional brain changes.PMID 22984439Read ↗

Alzheimer's disease amyloid-β pathology in the lens of the eyeSemantic proximity Read ↗

Relationships of visual impairment and eye conditions with imaging markers, cognition, and diagnoses of dementia: a bi-directional Mendelian randomization studySemantic proximity Read ↗

Sex- and APOE Genotype-Dependent Pain Susceptibility and Alzheimer's Risk Mediated by the Lipid Metabolism Enzyme LPCAT2.Semantic proximity Read ↗

Causal association among glaucoma, cerebral cortical structures, and Alzheimer's disease: insights from genetic correlation and Mendelian randomization.Semantic proximity Read ↗

The Associations Between Cataracts and Alzheimer's Disease: A Bidirectional Two-Sample Mendelian Randomization Study.Semantic proximity Read ↗

Disentangling the genetic overlap and causal relationships between primary open-angle glaucoma, brain morphology and four major neurodegenerative disordersSemantic proximity Read ↗

Meta-analysis of genome-wide association studies in multiethnic Asians identifies two loci for age-related nuclear cataract.Semantic proximity Read ↗

The link between apolipoprotein E, presenilin 1, and kinesin light chain 1 gene polymorphisms and age-related cortical cataracts in the Chinese population.Semantic proximity Read ↗

Genome-wide association study and polygenic risk scores of retinal thickness across the cognitive continuum: data from the NORFACE cohortSemantic proximity Read ↗

Association Between Wnt Target Genes and Cortical Volumes in Alzheimer’s DiseaseSemantic proximity Read ↗

Regional mosaic genomic heterogeneity in the elderly and in Alzheimer's disease as a correlate of neuronal vulnerability.Semantic proximity Read ↗

Association between single nucleotide polymorphisms in exon 3 of the alpha-A-crystallin gene and susceptibility to age-related cataract.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.