Article

Genetic liability to hip osteoarthritis confers neurovascular protection against Alzheimer’s disease despite depression-mediated phenotypic comorbidity

2026-03-04

Abstract excerpt

<h4>Background</h4> The relationship between hip osteoarthritis (hip OA) and Alzheimer’s disease (AD) presents a critical paradox within the emerging "bone-brain axis": widespread phenotypic comorbidity sharply contradicts evolutionary theories of biological antagonism. This study integrates longitudinal and multi-omic analyses to determine whether this clinical overlap masks an underlying genetic neuroprotection...

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Literature Corpus work: 17407cbe-3253-53a7-a140-9cf60c0ab2d5
DOI: 10.64898/2026.03.04.26347509

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