Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer's disease.

doi:10.1186/s40478-021-01199-2

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Article

Genome-wide analysis identifies a novel LINC-PINT splice variant associated with vascular amyloid pathology in Alzheimer's disease.

Acta neuropathologica communications - 21 May 2021

Reddy Joseph S, Allen Mariet, Ho Charlotte C G, Oatman Stephanie R, İş Özkan, Quicksall Zachary S, Wang Xue, Jin Jiangli, Patel Tulsi A, Carnwath Troy P, Nguyen Thuy T, Malphrus Kimberly G, Lincoln Sarah J, Carrasquillo Minerva M, Crook Julia E, Kanekiyo Takahisa, Murray Melissa E, Bu Guojun, Dickson Dennis W, Ertekin-Taner Nilüfer

Abstract excerpt

Cerebral amyloid angiopathy (CAA) contributes to accelerated cognitive decline in Alzheimer's disease (AD) dementia and is a common finding at autopsy. The APOEε4 allele and male sex have previously been reported to associate with increased CAA in AD. To inform biomarker and therapeutic target discovery, we aimed to identify additional genetic risk factors and biological pathways involved in this vascular...

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Identifiers

PMID: 34020725
DOI: 10.1186/s40478-021-01199-2
PMCID: PMC8147512

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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