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Article

Biochemical reconstitution of temozolomide-induced mutational processes.

The Journal of biological chemistry - 1 Nov 2025

Sanyal Mahima R, Sugiyama Tomohiko

Abstract excerpt

Temozolomide (TMZ), a DNA alkylator, is a chemotherapeutic agent for brain tumors, but the treatment induces a distinct pattern of mutations, known as a cancer mutational signature single-base substitution signature 11 (SBS11). Although the correlation between TMZ treatment and SBS11 mutations is very clear, the precise biochemical mechanisms that cause SBS11 have not been elucidated. TMZ can alkylate DNA at...

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Antineoplastic Agents, Alkylating
Dacarbazine
DNA Damage
DNA-Directed DNA Polymerase
DNA Polymerase III

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 40914245
DOI: 10.1016/j.jbc.2025.110676
PMCID: PMC12556801

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

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