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Article

Biochemical analysis of H2O2-induced mutation spectra revealed that multiple damages were involved in the mutational process.

DNA repair - 1 Feb 2024

Sugiyama Tomohiko, Sanyal Mahima R

Abstract excerpt

Reactive oxygen species (ROS) are a major threat to genomic integrity and believed to be one of the etiologies of cancers. Here we developed a cell-free system to analyze ROS-induced mutagenesis, in which DNA was exposed to H2O2 and then subjected to translesion DNA synthesis by various DNA polymerases. Then, frequencies of mutations on the DNA products were determined by using next-generation sequencing...

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Identifiers

PMID: 38154332
DOI: 10.1016/j.dnarep.2023.103617
PMCID: PMC10842480

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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