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Article

Biochemical reconstitution of heat-induced mutational processes.

PloS one - 1 Jan 2024

Sugiyama Tomohiko

Abstract excerpt

Non-enzymatic spontaneous deamination of 5-methylcytosine, producing thymine, is the proposed etiology of cancer mutational signature 1, which is the most predominant signature in all cancers. Here, the proposed mutational process was reconstituted using synthetic DNA and purified proteins. First, single-stranded DNA containing 5-methylcytosine at CpG context was incubated at an elevated temperature to accelerate...

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Identifiers

PMID: 39288122
DOI: 10.1371/journal.pone.0310601
PMCID: PMC11407675

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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