Mutagenesis mechanism of the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine.

doi:10.1093/nar/gkaa193

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Article

Mutagenesis mechanism of the major oxidative adenine lesion 7,8-dihydro-8-oxoadenine.

Nucleic acids research - 21 May 2020

Koag Myong-Chul, Jung Hunmin, Lee Seongmin

Abstract excerpt

Reactive oxygen species generate the genotoxic 8-oxoguanine (oxoG) and 8-oxoadenine (oxoA) as major oxidative lesions. The mutagenicity of oxoG is attributed to the lesion's ability to evade the geometric discrimination of DNA polymerases by adopting Hoogsteen base pairing with adenine in a Watson-Crick-like geometry. Compared with oxoG, the mutagenesis mechanism of oxoA, which preferentially induces A-to-C...

Topics

Adenine
Base Pairing
DNA Polymerase beta
DNA-Directed DNA Polymerase
Deoxyguanine Nucleotides
Humans
Kinetics
Mutagenesis
Mutation
Thymine Nucleotides

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Identifiers

PMID: 32282906
DOI: 10.1093/nar/gkaa193
PMCID: PMC7229865

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