Article
Comprehensive whole-genome sequencing reveals origins of mutational signatures associated with aging, mismatch repair deficiency and temozolomide chemotherapy.
Nucleic acids research - 7 Jan 2025
Hwang Taejoo, Sitko Lukasz Karol, Khoirunnisa Ratih, Navarro-Aguad Fernanda, Samuel David M, Park Hajoong, Cheon Banyoon, Mutsnaini Luthfiyyah, Lee Jaewoong, Otlu Burçak, Takeda Shunichi, Lee Semin, Ivanov Dmitri, Gartner Anton
Abstract excerpt
In a comprehensive study to decipher the multi-layered response to the chemotherapeutic agent temozolomide (TMZ), we analyzed 427 genomes and determined mutational patterns in a collection of ∼40 isogenic DNA repair-deficient human TK6 lymphoblast cell lines. We first demonstrate that the spontaneous mutational background is very similar to the aging-associated mutational signature SBS40 and mainly caused by...
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