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Replication across Regioisomeric Ethylated Thymidine Lesions by Purified DNA Polymerases

17 Oct 2013

Abstract excerpt

Causal links exist between smoking cigarettes and cancer development. Some genotoxic agents in cigarette smoke are capable of alkylating nucleobases in DNA, and higher levels of ethylated DNA lesions were observed in smokers than in nonsmokers. In this study, we examined comprehensively how the regioisomeric O(2)-, N3-, and O(4)-ethylthymidine (O(2)-, N3-, and O(4)-EtdT, respectively) perturb DNA replication...

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PMID: 24134187
DOI: 10.1021/tx4002995

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