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Comprehensive Whole Genome Sequencing Reveals Origins of Mutational Signatures Associated with Aging and Temozolomide Chemotherapy

2024-04-20

Abstract excerpt

In a comprehensive study to decipher the multi-layered response to the chemotherapeutic agent temozolomide (TMZ), we analyzed 427 genomes and determined mutational patterns in a collection of ∼40 isogenic DNA repair-deficient human TK6 lymphoblast cell lines. We demonstrate that the spontaneous mutational background is very similar to the aging-associated mutational signature SBS40 and mainly caused by polymerase...

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Literature Corpus work
dc829cab-9fc1-52cd-93e6-ae367e7d5d07
DOI
10.1101/2024.04.17.590003
Open publication

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Comprehensive Whole Genome Sequencing Reveals Origins of Mutational Signatures Associated with Aging and Temozolomide ChemotherapyDOI 10.1101/2024.04.17.590003
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