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Article

A phenotypic screen for novel small molecules that correct tau-mediated pathologies in human frontotemporal dementia neurons.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Sept 2025

Maxwell Hannah, Smith James, Campbell Tom, Clark Jason, La Rocca Rosanna, Paonessa Francesco, Sitnikov Sergey, Evans Mark, Maycox Peter, Livesey Frederick J

Abstract excerpt

INTRODUCTION: Mutations in the MAPT gene that are causal for frontotemporal dementia (FTD) lead to mislocalization of tau protein to the neuronal cell body, changing microtubule dynamics to disrupt the nuclear envelope and nucleocytoplasmic transport. METHODS: We report a high content imaging-based phenotypic screen to identify novel small molecules that correct nuclear envelope defects in human neurons...

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Share to Frontotemporal Dementia
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 40891380
DOI: 10.1002/alz.70620
PMCID: PMC12402808

Genes

MAPT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

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