Article

Targeting the acetyltransferase NAT10 corrects pathologies in human frontotemporal dementia neurons and extends lifespan in an in vivo <i>Drosophila</i> tauopathy model

2024-10-22

Abstract excerpt

<h4>ABSTRACT</h4> Disruption of the neuronal nuclear membrane and perturbation of nucleocytoplasmic transport are features of neurodegenerative diseases, including Alzheimer’s disease, that involve the microtubule-associated protein tau (MAPT). We previously identified that missense and splicing mutations in the MAPT gene, causal for frontotemporal dementia, result in nuclear envelope deformation and disrupted nu...

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Literature Corpus work: db70e6ce-501f-59aa-9de4-8ae083f61195
DOI: 10.1101/2024.10.19.619211

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