Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neurons

10 Oct 2016

Abstract excerpt

Abstract Mutations in the gene MAPT encoding tau, a microtubules-associated protein, cause a subtype of familial neurodegenerative disorder, known as frontotemporal lobar degeneration tauopathy (FTLD-Tau), which presents with dementia and is characterized by atrophy in the frontal and temporal lobes of the brain. Although induced pluripotent stem cell (iPSC) technology has facilitated the investigation of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Nuclear Receptors and Signaling
Share to Prion Diseases and Protein Misfolding

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 27721502
DOI: 10.1038/srep34904

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Calcium dysregulation contributes to neurodegeneration in FTLD patient iPSC-derived neuronsPMID 27721502Read ↗

Tau depletion in human neurons mitigates Aβ-driven toxicitySemantic proximity Read ↗

Human Induced Pluripotent Stem Cell Models of Frontotemporal Dementia With Tau PathologySemantic proximity Read ↗

MAPT genotype-dependent mitochondrial aberration and ROS production trigger dysfunction and death in cortical neurons of patients with hereditary FTLD.Semantic proximity Read ↗

Tau inhibits mitochondrial calcium efflux and makes neurons vulnerable to calcium-induced cell death.Semantic proximity Read ↗

The TAU isoform 1N4R restores vulnerability of MAPT knockout human iPSC-derived neurons to Amyloid beta-induced neuronal dysfunctionSemantic proximity Read ↗

Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein.Semantic proximity Read ↗

Human iPSC-Derived Neuronal Model of Tau-A152T Frontotemporal Dementia Reveals Tau-Mediated Mechanisms of Neuronal Vulnerability.Semantic proximity Read ↗

Conserved gene signatures shared among MAPT mutations reveal defects in calcium signalingSemantic proximity Read ↗

Pathological Progression Induced by the Frontotemporal Dementia-Associated R406W Tau Mutation in Patient-Derived iPSCsSemantic proximity Read ↗

Patient-derived Induced Pluripotent Stem Cells as a Model to Study Frontotemporal Dementia PathologiesSemantic proximity Read ↗

Integrative system biology analyses of CRISPR-edited iPSC-derived neurons and human brains reveal deficiencies of presynaptic signaling in FTLD and PSPSemantic proximity Read ↗

Generation of a human induced pluripotent stem cell-based model for tauopathies combining three microtubule-associated protein TAU mutations which displays several phenotypes linked to neurodegeneration.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.