Article

Morphological profiling by Cell Painting in human neural progenitor cells classifies hit compounds in a pilot drug screen for Alzheimer’s disease

2023-01-18

Abstract excerpt

1 Alzheimer’s disease (AD) accounts for 60-70% of dementia cases. Current treatments are inadequate and there is a need to develop new approaches to AD drug discovery. We chose to develop a cell phenotype-based drug screen centred on the AD-risk gene, SORL1 , which encodes the protein SORLA. Increased AD risk has been repeatedly linked to variants in SORL1 , particularly those that confer loss of, or decreased,...

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Literature Corpus work: 69d50854-e37b-55f7-ab62-0fc6051338fa
DOI: 10.1101/2023.01.16.523559

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