Article

Bezafibrate treatment rescues neurodevelopmental and neurodegenerative defects in 3D cortical organoid model of MAPT frontotemporal dementia

2024-08-03

Abstract excerpt

<h4>ABSTRACT</h4> <h4>INTRODUCTION</h4> The intronic MAPT mutation IVS10+16 is linked to familiar frontotemporal dementia, causing hyperphosphorylation and accumulation of tau protein, resulting in synaptic and neuronal loss and neuroinflammation in patients. This mutation disrupts MAPT gene splicing, increasing exon 10 inclusion and leading to an imbalance of 3R and 4R Tau isoforms. <h4>METHODS</h4> We generat...

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Literature Corpus work: 35a821c5-c788-595a-a539-0ba968587a1e
DOI: 10.1101/2024.08.02.606317

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