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Article

Bezafibrate treatment rescues neurodevelopmental and neurodegenerative defects in 3D cortical organoid model of MAPT frontotemporal dementia.

Alzheimer's & dementia : the journal of the Alzheimer's Association - 1 Aug 2025

Cordella Federica, Mautone Lorenza, Salerno Debora, Tondo Lucrezia, Ghirga Silvia, D'Antoni Chiara, Parente Erika, Romeo Maria Anele, Cirone Mara, Bezzi Paola, Di Angelantonio Silvia

Abstract excerpt

INTRODUCTION: The intronic MAPT mutation IVS10+16 is linked to familial frontotemporal dementia, causing hyperphosphorylation and accumulation of tau protein, resulting in synaptic and neuronal loss and neuroinflammation in patients. This mutation disrupts MAPT gene splicing, increasing exon 10 inclusion and leading to an imbalance of 3R and 4R Tau isoforms. METHODS: We generated patterned cortical organoids from...

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Identifiers

PMID: 40810332
DOI: 10.1002/alz.70419
PMCID: PMC12351496

Genes

MAPT

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