Pharmacologic reductions of total tau levels; implications for the role of microtubule dynamics in regulating tau expression.

Abstract excerpt

UNLABELLED: The microtubule-associated protein tau (MAPT) is a pathological component of several neurodegenerative diseases and clinical dementias. Here, we have investigated the effects of a series of commercially available FDA-approved compounds and natural products on total tau protein levels using a cell-based approach that allows for the rapid and efficient measurement of changes in protein expression....

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