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Article

EMG1 cooperates with GRHL3 in β-catenin-mediated surface ectoderm differentiation to regulate neural tube closure.

Development (Cambridge, England) - 1 Aug 2025

Kimura-Yoshida Chiharu, Mochida Kyoko, Matsuno Chihiro, Kano Keiko, Mishiro-Sato Emi, Matsuo Isao

Abstract excerpt

Grainyhead-like transcription factor 3 (GRHL3) directs surface ectoderm differentiation under the control of the canonical Wnt/β-catenin pathway. However, the molecular mechanisms that control nuclear GRHL3 expression through β-catenin are not fully understood. Here, we show that the essential for mitotic growth 1 (EMG1) protein constitutes a protein complex with GRHL3, and that EMG1 is required for correct...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 40761126
DOI: 10.1242/dev.204700

Genes

GRHL3
EMG1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

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