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Gorlin Syndrome: Recent Advances in Genetic Testing and Molecular and Cellular Biological Research

13 Oct 2020

Abstract excerpt

Gorlin syndrome is a skeletal disorder caused by a gain of function mutation in Hedgehog (Hh) signaling. The Hh family comprises of many signaling mediators, which, through complex mechanisms, play several important roles in various stages of development. The Hh information pathway is essential for bone tissue development. It is also the major driver gene in the development of basal cell carcinoma and...

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PMID: 33066274
DOI: 10.3390/ijms21207559

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