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Article

Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning.

European journal of human genetics : EJHG - 1 Feb 2017

Taniguchi Kenichiro, Anderson Anoush E, Melhuish Tiffany A, Carlton Anne L, Manukyan Arkadi, Sutherland Ann E, Wotton David

Abstract excerpt

Holoprosencephaly (HPE) is a prevalent craniofacial developmental disorder that has both genetic and environmental causes. The gene encoding TG-interacting factor 1 (TGIF1) is among those that are routinely screened in HPE patients. However, the mechanisms by which TGIF1 variants cause HPE are not fully understood. TGIF1 is a transcriptional repressor that limits the output of the Transforming Growth Factor ß...

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Share to Hedgehog Proteins
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 27924807
DOI: 10.1038/ejhg.2016.164
PMCID: PMC5255961

Genes

TGIF1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Genetic and Molecular Analyses indicate independent effects of TGIFs on Nodal and Gli3 in neural tube patterning.PMID 27924807Read ↗

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