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Article

The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity.

Developmental biology - 15 Jan 2011

Boglev Yeliz, Wilanowski Tomasz, Caddy Jacinta, Parekh Vishwas, Auden Alana, Darido Charbel, Hislop Nikki R, Cangkrama Michael, Ting Stephen B, Jane Stephen M

Abstract excerpt

The Grainy head-like 3 (Grhl3) gene encodes a transcription factor that plays essential roles in epidermal morphogenesis during embryonic development, with deficient mice exhibiting failed skin barrier formation, defective wound repair, and loss of eyelid fusion. Despite sharing significant sequence homology, overlapping expression patterns, and an identical core consensus DNA binding site, the other members of...

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Source

Identifiers

PMID: 21081122
DOI: 10.1016/j.ydbio.2010.11.011

Genes

GRHL3
GRHL2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity.PMID 21081122Read ↗

Grainyhead-like (Grhl) Target Genes in Development and CancerSemantic proximity Read ↗

The Grainyhead-like epithelial transactivator Get-1/Grhl3 regulates epidermal terminal differentiation and interacts functionally with LMO4.Semantic proximity Read ↗

Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure.Semantic proximity Read ↗

Grainyhead genes and mammalian neural tube closure.Semantic proximity Read ↗

Interrogating the Grainyhead-like 2 (Grhl2) genomic locus identifies an enhancer element that regulates palatogenesis in mouse.Semantic proximity Read ↗

Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice.Semantic proximity Read ↗

A homolog of Drosophila grainy head is essential for epidermal integrity in mice.Semantic proximity Read ↗

Loss of the epithelial transcription factor grhl3 leads to variably penetrant developmental phenotypes in zebrafish.Semantic proximity Read ↗

Epidermal wound repair is regulated by the planar cell polarity signaling pathway.Semantic proximity Read ↗

Grainy head promotes expression of septate junction proteins and influences epithelial morphogenesis.Semantic proximity Read ↗

Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension.Semantic proximity Read ↗

Mutations in GRHL2 result in an autosomal-recessive ectodermal Dysplasia syndrome.Semantic proximity Read ↗

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