Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice.

Human molecular genetics - 15 Dec 2018

De Castro Sandra C P, Gustavsson Peter, Marshall Abigail R, Gordon William M, Galea Gabriel, Nikolopoulou Evanthia, Savery Dawn, Rolo Ana, Stanier Philip, Andersen Bogi, Copp Andrew J, Greene Nicholas D E

Abstract excerpt

The genetic basis of human neural tube defects (NTDs), such as anencephaly and spina bifida (SB), is complex and heterogeneous. Grainyhead-like genes represent candidates for involvement in NTDs based on the presence of SB and exencephaly in mice carrying loss-of-function alleles of Grhl2 or Grhl3. We found that reinstatement of Grhl3 expression, by bacterial artificial chromosome (BAC)-mediated transgenesis,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Animals, Genetically Modified
Share to Embryonic Development

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Loss of Function Mutation

Share to Nerve Tissue Proteins

Share to Neural Tube Defects

Share to Protein Multimerization

Share to Spinal Dysraphism

Source

Open in PubMed Open full text

Identifiers

PMID: 30189017
DOI: 10.1093/hmg/ddy313
PMCID: PMC6276835

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice.PMID 30189017Read ↗

Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse.Semantic proximity Read ↗

Increased expression of Grainyhead-like-3 rescues spina bifida in a folate-resistant mouse model.Semantic proximity Read ↗

A non-coding insertional mutation of Grhl2 causes gene over-expression and multiple structural anomalies including cleft palate, spina bifida and encephalocele.Semantic proximity Read ↗

Grainyhead genes and mammalian neural tube closure.Semantic proximity Read ↗

Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension.Semantic proximity Read ↗

Grainyhead-like (Grhl) Target Genes in Development and CancerSemantic proximity Read ↗

Inositol- and folate-resistant neural tube defects in mice lacking the epithelial-specific factor Grhl-3.Semantic proximity Read ↗

Interrogating the Grainyhead-like 2 (Grhl2) genomic locus identifies an enhancer element that regulates palatogenesis in mouse.Semantic proximity Read ↗

The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity.Semantic proximity Read ↗

Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure.Semantic proximity Read ↗

Two rare variants reveal the significance of Grainyhead-like 3 Arginine 391 underlying non-syndromic cleft palate only.Semantic proximity Read ↗

Loss of the epithelial transcription factor grhl3 leads to variably penetrant developmental phenotypes in zebrafish.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.