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Article

Cumulative inactivation of Nell-1 in Wnt1 expressing cell lineages results in craniofacial skeletal hypoplasia and postnatal hydrocephalus.

Cell death and differentiation - 1 Apr 2020

Chen Xiaoyan, Wang Huiming, Yu Mengliu, Kim Jong Kil, Qi Huichuan, Ha Pin, Jiang Wenlu, Chen Eric, Luo Xiangyou, Needle Ryan Brent, Baik Lloyd, Yang Cathryn, Shi Jiejun, Kwak Jin Hee, Ting Kang, Zhang Xinli, Soo Chia

Abstract excerpt

Upregulation of Nell-1 has been associated with craniosynostosis (CS) in humans, and validated in a mouse transgenic Nell-1 overexpression model. Global Nell-1 inactivation in mice by N-ethyl-N-nitrosourea (ENU) mutagenesis results in neonatal lethality with skeletal abnormalities including cleidocranial dysplasia (CCD)-like calvarial bone defects. This study further defines the role of Nell-1 in craniofacial...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 31582804
DOI: 10.1038/s41418-019-0427-1
PMCID: PMC7206096

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CS

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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