Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Grainyhead-like (Grhl) Target Genes in Development and Cancer

1 Mar 2022

Abstract excerpt

Grainyhead-like (GRHL) factors are essential, highly conserved transcription factors (TFs) that regulate processes common to both natural cellular behaviours during embryogenesis, and de-regulation of growth and survival pathways in cancer. Serving to drive the transcription, and therefore activation of multiple co-ordinating pathways, the three GRHL family members (GRHL1-3) are a critical conduit for modulating...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer-related Molecular Pathways
Share to Epigenetics and DNA Methylation
Share to Genomics and Chromatin Dynamics

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 35269877
DOI: 10.3390/ijms23052735

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Grainyhead-like (Grhl) Target Genes in Development and CancerPMID 35269877Read ↗

The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity.Semantic proximity Read ↗

Grainyhead genes and mammalian neural tube closure.Semantic proximity Read ↗

Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension.Semantic proximity Read ↗

Interrogating the Grainyhead-like 2 (Grhl2) genomic locus identifies an enhancer element that regulates palatogenesis in mouse.Semantic proximity Read ↗

A non-coding insertional mutation of Grhl2 causes gene over-expression and multiple structural anomalies including cleft palate, spina bifida and encephalocele.Semantic proximity Read ↗

Alternative splicing and start sites: Lessons from the Grainyhead-like family.Semantic proximity Read ↗

Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice.Semantic proximity Read ↗

GLIS1–3 transcription factors: critical roles in the regulation of multiple physiological processes and diseasesSemantic proximity Read ↗

Grhl2 determines the epithelial phenotype of breast cancers and promotes tumor progression.Semantic proximity Read ↗

Mutations in GRHL2 result in an autosomal-recessive ectodermal Dysplasia syndrome.Semantic proximity Read ↗

GRHL2-controlled gene expression networks in luminal breast cancerSemantic proximity Read ↗

Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.