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Article

Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure.

Disease models & mechanisms - 25 Mar 2020

Carpinelli Marina R, de Vries Michael E, Auden Alana, Butt Tariq, Deng Zihao, Partridge Darren D, Miles Lee B, Georgy Smitha R, Haigh Jody J, Darido Charbel, Brabletz Simone, Brabletz Thomas, Stemmler Marc P, Dworkin Sebastian, Jane Stephen M

Abstract excerpt

Cleft lip and palate are common birth defects resulting from failure of the facial processes to fuse during development. The mammalian grainyhead-like (Grhl1-3) genes play key roles in a number of tissue fusion processes including neurulation, epidermal wound healing and eyelid fusion. One family member, Grhl2, is expressed in the epithelial lining of the first pharyngeal arch in mice at embryonic day (E)10.5,...

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Identifiers

PMID: 32005677
DOI: 10.1242/dmm.042218
PMCID: PMC7104862

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Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure.PMID 32005677Read ↗

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