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Article

Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension.

Scientific reports - 14 Dec 2017

Miles Lee B, Darido Charbel, Kaslin Jan, Heath Joan K, Jane Stephen M, Dworkin Sebastian

Abstract excerpt

The grainyhead-like (grhl) transcription factors play crucial roles in craniofacial development, epithelial morphogenesis, neural tube closure, and dorso-ventral patterning. By utilising the zebrafish to differentially regulate expression of family members grhl2b and grhl3, we show that both genes regulate epithelial migration, particularly convergence-extension (CE) type movements, during embryogenesis. Genetic...

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Identifiers

PMID: 29242584
DOI: 10.1038/s41598-017-17898-7
PMCID: PMC5730563

Genes

EVL

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