Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interrogating the Grainyhead-like 2 (Grhl2) genomic locus identifies an enhancer element that regulates palatogenesis in mouse.

Developmental biology - 15 Mar 2020

de Vries Michael, Carpinelli Marina, Rutland Emilie, Hatzipantelis Aaron, Partridge Darren, Auden Alana, Anderson Peter J, De Groef Bert, Wu Han, Osterwalder Marco, Visel Axel, Jane Stephen M, Dworkin Sebastian

Abstract excerpt

The highly-conserved Grainyhead-like (Grhl) transcription factors are critical regulators of embryogenesis that regulate cellular survival, proliferation, migration and epithelial integrity, especially during the formation of the craniofacial skeleton. Family member Grhl2 is expressed throughout epithelial tissues during development, and loss of Grhl2 function leads to significant defects in neurulation,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Enhancer Elements, Genetic
Share to Gene Deletion

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Regulation, Developmental

Share to Genes, Reporter

Share to Genetic Loci

Share to Neural Tube

Share to Neural Tube Defects

Share to Palate

Source

Open in PubMed Open full text

Identifiers

PMID: 31782997
DOI: 10.1016/j.ydbio.2019.11.015
PMCID: PMC7984931

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interrogating the Grainyhead-like 2 (Grhl2) genomic locus identifies an enhancer element that regulates palatogenesis in mouse.PMID 31782997Read ↗

Inactivation of Zeb1 in GRHL2-deficient mouse embryos rescues mid-gestation viability and secondary palate closure.Semantic proximity Read ↗

A non-coding insertional mutation of Grhl2 causes gene over-expression and multiple structural anomalies including cleft palate, spina bifida and encephalocele.Semantic proximity Read ↗

Grainyhead-like (Grhl) Target Genes in Development and CancerSemantic proximity Read ↗

Grainyhead genes and mammalian neural tube closure.Semantic proximity Read ↗

Overexpression of Grainyhead-like 3 causes spina bifida and interacts genetically with mutant alleles of Grhl2 and Vangl2 in mice.Semantic proximity Read ↗

The unique and cooperative roles of the Grainy head-like transcription factors in epidermal development reflect unexpected target gene specificity.Semantic proximity Read ↗

Mis-expression of grainyhead-like transcription factors in zebrafish leads to defects in enveloping layer (EVL) integrity, cellular morphogenesis and axial extension.Semantic proximity Read ↗

Evidence for multiple roles for grainyhead-like 2 in the establishment and maintenance of human mucociliary airway epitheliumSemantic proximity Read ↗

Golgb1 regulates protein glycosylation and is crucial for mammalian palate development.Semantic proximity Read ↗

Over-expression of Grhl2 causes spina bifida in the Axial defects mutant mouse.Semantic proximity Read ↗

GRHL2-controlled gene expression networks in luminal breast cancerSemantic proximity Read ↗

Long-range enhancers regulating Myc expression are required for normal facial morphogenesis.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.