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A new IDH-independent hypermethylation phenotype is associated with astrocyte-like cell state in glioblastoma

3 Jul 2025

Abstract excerpt

BACKGROUND: DNA methylation plays a crucial role in cancer development and progression and has been linked to genetically and clinically distinct tumor classes, including IDH-mutated and IDH-wildtype adult-type diffuse gliomas. Here, we identify a CpG-island methylator phenotype (CIMP) that characterizes the receptor tyrosine kinase 2 (RTK2) subtype of IDH-wildtype glioblastoma. RESULTS: This RTK2-CIMP affects...

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Share to Epigenetics and DNA Methylation
Share to Glioma Diagnosis and Treatment
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PMID: 40611337
DOI: 10.1186/s13059-025-03670-y

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