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Article

Genetic and epigenetic instability as an underlying driver of progression and aggressive behavior in IDH-mutant astrocytoma.

Acta neuropathologica - 16 Jul 2024

Richardson Timothy E, Walker Jamie M, Hambardzumyan Dolores, Brem Steven, Hatanpaa Kimmo J, Viapiano Mariano S, Pai Balagopal, Umphlett Melissa, Becher Oren J, Snuderl Matija, McBrayer Samuel K, Abdullah Kalil G, Tsankova Nadejda M

Abstract excerpt

In recent years, the classification of adult-type diffuse gliomas has undergone a revolution, wherein specific molecular features now represent defining diagnostic criteria of IDH-wild-type glioblastomas, IDH-mutant astrocytomas, and IDH-mutant 1p/19q-codeleted oligodendrogliomas. With the introduction of the 2021 WHO CNS classification, additional molecular alterations are now integrated into the grading of...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 39012509
DOI: 10.1007/s00401-024-02761-7
PMCID: PMC11252228

Genes

CDKN2A

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